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Extend Podcast with Darshan Shah, MD

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Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results. That's why this podcast is all about cutting through the noise on how to turn back the aging clock. I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health. Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.

Latest episodes

206. Dr. Pamela Smith: The Truth About Hormone Replacement Therapy—HRT, Menopause & Cancer Risk

Hormones influence far more than reproductive health. They affect your sleep, mood, metabolism, muscle, bone health, brain function, stress response, and how you age—yet hormone health is still often reduced to a handful of numbers on a standard blood test. In this episode, I'm joined by Dr. Pamela Smith, a physician who has spent decades practicing and teaching personalized medicine, to break dow

8 Oct 2026 · 53 min
205. Rajeev Kapur: How AI Is Transforming Healthcare

What if AI could change the way we understand, manage, and optimize our health? In today's episode, my guest is Rajeev Kapur, a leading AI advisor, educator, speaker, and author who helps non technical leaders understand how to turn artificial intelligence into practical, actionable results. We dive into AI in healthcare, personalized health, health optimization, and the ideas behind our co author

6 Oct 2026 · 1 h 3 min
204. Dr. Cassie Smith: Fix Your Gut, Fix Your Hormones, Fix Your Health

What if your gut health is the missing piece behing your hormones, energy, metabolism, and how you feel every day? Today, I sit down with Dr. Cassie Smith, a double board-certiied endocrinologist and internal medicine physician who has taken a deeper look at the connection between gut health, hormones, thryoid function, metabolism, and overall health. We talk about why "normal" lab results don't a

1 Oct 2026 · 55 min
203. Sat Randhawa: Can You Train Your Brain? QEEG & Neurofeedback

What if we stopped guessing about the brain and started measuring it? In today's episode, my guest is Sat Randhawa of One-Hype Wellness, where he and his team are focused on using brain mapping and neurotechnology to better understand how each individual brain functions. We dive into QEEG brain mapping, neurofeedback, neuroplasticity, and brainwave analysis - and explore why there may not be a one

29 Sep 2026 · 1 h 10 min
202. Dr. Colleen Cutcliffe: The Fiber-Gut Connection: How to Improve Your Microbiome, Blood Sugar & Cholesterol

Most people know they should eat more fiber. But what we're learning about fiber, gut health, and the microbiome goes far beyond digestion. Your gut contains trillions of microbes that depend on what you eat—and different types of fiber feed different bacteria. Those microbes can influence everything from blood sugar regulation and metabolic health to cholesterol and the way your digestive system

24 Sep 2026 · 52 min
201: Joey Munoz: The Truth About Nutrition, Protein, Weight Loss & Muscle

What if the biggest mistake you're making with your health isn't what you're eating - but the way you're thinking about nutrition in the first place? In this episode, I'm joined by Dr. Joey Munoz, a PhD in Nutrition Science and an evidence-based nutrition and fitness educator. We have a fascinating conversation about why so many traditional approaches to dieting fail, what actually makes a healthy

22 Sep 2026 · 1 h 23 min
200. Dr. Will Cole: How to Heal Your Cells—Mitochondria, Peptides & the Science of Aging

What if the fatigue, brain fog, low energy, and other symptoms we associate with getting older actually begin much deeper—at the level of our cells? I've followed Dr. Will Cole's work for years, and his approach to gut health and functional medicine played an important role in my own health journey. Now he's taking that conversation one step further with his new book, Heal Your Cells, exploring wh

17 Sep 2026 · 1 h 9 min
199. Dr. Jeffrey Wiegers: Stem Cells Explained—What They Can Do Now & What's Coming Next

What if medicine could do more than manage disease—and actually help the body repair itself? Regenerative medicine is moving quickly, but the world of stem cells, PRP, exosomes, and cellular therapies can be incredibly confusing. In this conversation, I sit down with Dr. Wiggers to separate what we can do today from what may be coming next. We start with the basics: what stem cells actually are, h

15 Sep 2026 · 1 h 10 min
198. Dr. Bryce Appelbaum: Your Eyes Are Connected to Everything—Focus, Balance, Brain Health & Aging

What if your eyesight is 20/20—but your vision still isn't working the way it should? Dr. Bryce Appelbaum specializes in functional vision and the connection between the eyes and the brain. In this conversation, he explains why seeing clearly is only one piece of vision—and how the brain's ability to process what we see can influence reading, focus, coordination, balance, motion sickness, athletic

10 Sep 2026 · 58 min
197. Ben Greenfield: When Biohacking Goes Too Far—What Actually Matters for Longevity

What happens when optimizing your health starts taking over your life? Ben Greenfield has spent decades at the forefront of biohacking, fitness, human performance, and longevity—testing the technologies, tracking the biomarkers, competing at an elite level, and pushing his body to its limits. But after years of relentless self-optimization, he realized something important: living longer means very

8 Sep 2026 · 57 min
196: Dr. Jill Carnahan: Is Mold Making You Sick? Hidden Toxins, Symptoms & Detox

What if the fatigue, brain fog, inflammation, or unexplained symptoms you're experiencing aren't starting inside your body—but in the environment around you? Dr. Jill Carnahan knows this story from both sides of the exam room. At just 25, while still in medical school, she was diagnosed with breast cancer. Months after aggressive chemotherapy, she was diagnosed with Crohn's disease. Her search for

3 Sep 2026 · 54 min
195: Jeff Byers: Inside the Supplement Industry: The 4 Supplements That Actually Matter

Walk into any supplement aisle—or scroll through social media—and you'll find thousands of products promising better energy, performance, brain health, and longevity. But which supplements actually work? And how do you know what's really inside them? My guest is Jeff Byers, a former NFL athlete and the co-founder of Momentous, a performance nutrition company built around rigorous standards for sup

1 Sep 2026 · 1 h 20 min
194: Dr. Mark Hyman: Why You're Still Sick—Finding the Root Cause With Functional Medicine

What if the reason you're still sick isn't because there's no answer—but because no one has looked deeply enough for the root cause? My guest, Dr. Mark Hyman, is one of the world's leading voices in functional medicine, a bestselling author, physician, and founder of The UltraWellness Center. After navigating serious health challenges himself, he built his career around a different approach to chr

27 Aug 2026 · 58 min
193: Dr. Sasha Hamdani: ADHD, Anxiety and How to Regulate your Emotions

What if ADHD isn't just an attention problem—but also a problem of emotional regulation? My guest, Dr. Sasha Hamdani, is a board-certified psychiatrist, ADHD specialist, author, and someone who has lived with ADHD herself. She brings a unique perspective to a part of ADHD that often gets overlooked: emotional sensitivity. We explore why some people feel emotions faster, more deeply, and for longer

25 Aug 2026 · 50 min
192: Dr. Perlmutter: How to Protect Your Brain From Alzheimer's & Cognitive Decline

What if your risk of Alzheimer's isn't predetermined by your genes—but influenced by the metabolic health of your brain? My guest, Dr. David Perlmutter, is a board-certified neurologist, six-time New York Times bestselling author, and one of the world's leading voices on brain health and neurodegenerative disease. His latest work reveals a fascinating shift in how we understand Alzheimer's and Par

20 Aug 2026 · 1 h 9 min
191: Kiran Krishnan: How to Rebuild Your Gut Microbiome & Reduce Inflammation

What if the biggest mistake we're making with gut health is treating the microbiome like a list of bacteria instead of a living ecosystem? Your gut is home to trillions of microorganisms that influence inflammation, metabolism, immune function, hormones, brain health, and longevity. But modern life—from ultra-processed foods and antibiotics to pesticides, chronic stress, and inadequate fiber—may b

18 Aug 2026 · 1 h 11 min
190. Dr. William Harris: 90% of Americans Are Low in This Critical Longevity Nutrient

What if one of the most important markers for your heart, brain, and longevity is something most people have never measured? AND roughly 90% of Americans aren't in the optimal range for? In this episode, I sit down with Dr. William Harris, one of the world's leading experts on Omega-3 fatty acids and the co-inventor of the Omega-3 Index, a test he helped develop more than 20 years ago. Dr. Harris

13 Aug 2026 · 58 min
189. Dr. Florence Comite: The 5 Biomarkers That Predict How You'll Age

What if aging isn't something you simply accept - but something you can measure, predict, and even reverse? Most of us are told our lab work is "normal," yet chronic disease often develops silently for years before symptoms appear. Dr. Florence Comite, one of the world's leading pioneers in precision medicine, is explaining why conventional medicine often misses the earliest signs of diesease- and

11 Aug 2026 · 35 min
188. James Beshara: How to Find Productivity Without the Hustle

We're living in a culture that celebrates being busy. More coffee. More hours. More hustle. But what if those things are actually making you less productive? The truth is, many high performers are stuck in a cycle of chasing energy instead of creating it. We rely on caffeine to wake up, push through stress, and squeeze more into each day - only to end up burned out, distracted, and wondering why s

6 Aug 2026 · 1 h 6 min
187. Dr. Izabella Wentz: 30+ Root Causes Behind An IBS Diagnosis

Hashimotos isn't just a thyroid disease-it may actually begin in the gut. If you've been told your thyroid labs are "normal" but you still struggle with fatigue, bloating, constipation, IBS, or autoimmune symptoms, this episode could change the way you think about your health. I sit down with Dr. Izabella Wentz, PharmD-better known as the Thyroid Pharmacist and one of the world's leading experts o

4 Aug 2026 · 59 min